Development of a Practical Telescoped Process to Prepare (P)-7-(2-Amino-6-fluorophenyl)-4-hydroxy-6-(trifluoromethyl)pyrido[3,4-d]pyrimidin-8(7H)-one: a Key Intermediate of KRASG12C Inhibitor GH35-Reference-Cited by-同舟云学术

Development of a Practical Telescoped Process to Prepare (P)-7-(2-Amino-6-fluorophenyl)-4-hydroxy-6-(trifluoromethyl)pyrido[3,4-d]pyrimidin-8(7H)-one: a Key Intermediate of KRAS^G12C Inhibitor GH35

Published:2024-09-13 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Zuo Gaolei¹,Xu Haojie¹²³,Zhang Yaobin¹,Liu Zhi¹,Tu Jinyue¹,Gou Donghui¹,Fu Peng⁴,Huang Haifeng⁵,Ren Jianhua⁵,Hu Yuanyuan⁵,Liu Feng²³^ORCID,Li Jie Jack¹,Zhang Guiping¹^ORCID

Affiliation:

1. Center for Drug Design and Development Suzhou, Genhouse Bio Co., Ltd, No. 1 Xinze Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China

2. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China

3. Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, College of Pharmaceutical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China

4. MuJin Chem. Co., Ltd, No. 388 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China

5. Bellen Chemistry Co., Ltd, Building 9, Courtyard 10, Linhe Street, ShunYi District, Beijing 101300, China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00279

Reference19 articles.

1. Drugging the undruggable RAS: Mission Possible?

2. Prognostic and Predictive Value inKRASin Non–Small-Cell Lung Cancer

3. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

4. Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS^G12C Inhibitor

5. Development of Adagrasib’s Commercial Manufacturing Route