Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-trifluoroacetate Salt-Reference-Cited by-同舟云学术

Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-trifluoroacetate Salt

Published:2019-10-07 Issue:11 Volume:23 Page:2464-2469
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Chen Junhua¹,Park Jun¹,Kirk Sharon M.¹,Chen Hung-Ching¹,Li Xiangqin¹,Lippincott Daniel J.¹,Melillo Bruno¹,Smith Amos B.¹^ORCID

Affiliation:

1. Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00353

Reference17 articles.

1. UNAID: Global AIDS Update 2017 UNAIDS, United Nations High Level Meeting on Ending AIDS, New York, 2017.

2. Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

3. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

4. Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition

5. Identification of N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4

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