Development of a Scalable Route for a Highly Polar Heterocyclic Aminocyclopropyl Building Block-Reference-Cited by-同舟云学术

Development of a Scalable Route for a Highly Polar Heterocyclic Aminocyclopropyl Building Block

Published:2020-08-20 Issue:9 Volume:24 Page:1735-1742
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Schäfer Gabriel¹^ORCID,Ahmetovic Muhamed¹,Fleischer Tony¹,Abele Stefan¹

Affiliation:

1. Chemistry Process R&D, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00358

Reference24 articles.

1. Yeung, K. S.; Parcella, K. E.; Bender, J. A.; Beno, B. R.; Grant-Young, K. A.; Han, Y.; Hewawasam, P.; Kadow, J. F.; Nickel, A. Compounds for the treatment of hepatitis C. US8,048,8872011.

2. Process Development and Pilot-Plant Synthesis of (S)-tert-Butyl 1-Oxo-1-(1-(pyridin-2-yl)cyclopropylamino)propan-2-ylcarbamate: Studies on the Scale-Up of Kulinkovich–Szymoniak Cyclopropanation

3. Practical Synthesis of a 6-Triazolylazabicyclo[3.1.0]hexane

4. Use of a Curtius Rearrangement as Part of the Multikilogram Manufacture of a Pyrazine Building Block

5. Route Optimization and Manufacture of Multihundred Grams of a Ghrelin Receptor Agonist

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