Expedited Kilolab Development of AZD7624 Using Kulinkovich-de Meijere Cyclopropanation-Reference-Cited by-同舟云学术

Expedited Kilolab Development of AZD7624 Using Kulinkovich-de Meijere Cyclopropanation

Published:2021-09-28 Issue:10 Volume:25 Page:2351-2366
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ashok Mithun¹,J Ashwini D.¹,Leuser Helena²,Malapati Ajaya K.¹,Parker Jeremy S.¹^ORCID,Rowley Naomi A.³,Steven Alan³^ORCID,Timms Lee¹,Tyler Simon N. G.³,Whitmarsh Samuel³

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, AstraZeneca R&D, Macclesfield SK10 2NA, U.K.

2. Chemical Development, Carbogen Amcis AG, Hunzenschwil CH-5502, Switzerland

3. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00283

Reference42 articles.

1. Emerging role of MAP kinase pathways as therapeutic targets in COPD

2. Differential anti-inflammatory effects of budesonide and a p38 MAPK inhibitor AZD7624 on COPD pulmonary cells

3. The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial

4. Cooper, A. E.; Luker, T. J.; Schmidt, J. A. Preparation of pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient. WO 2010071583 A1, 2010.

5. Brough, S.; Evans, R.; Luker, T. J.; Raubo, P. Pyrazinone derivatives and their use in the treatment of lung diseases and their preparation. WO 2009001132 A1, 2008.

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