Practical and Scalable Method for Manufacturing AZD4604, A Potent and Selective JAK1 Inhibitor-Reference-Cited by-同舟云学术

Practical and Scalable Method for Manufacturing AZD4604, A Potent and Selective JAK1 Inhibitor

Published:2023-06-15 Issue:7 Volume:27 Page:1317-1329
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Pithani Subhash¹^ORCID,Aurell Carl-Johan¹,Lindhagen Marika¹,Nunn Michael²,Berggren Kristina³,Emtenäs Hans¹

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg SE 431 83, Mölndal, Sweden

2. Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, Macclesfield SK10 2NA, United Kingdom

3. Respiratory & Immunology, Biopharmaceuticals R&D, AstraZeneca, Gothenburg SE 431 83, Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00077

Reference23 articles.

1. aGlobal Asthma Network. The Global Asthma Report. http://www.globalasthmareport.org/ (accessed July 16, 2021).

2. Asthma

3. Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

4. bClinicalTrials.gov. A Clinical Trial in Healthy Volunteers and Patients with Mild Asthma to Investigate a New Medicine (AZD4604) for the Treatment of Asthma (NCT04769869). https://clinicaltrials.gov/ct2/show/NCT04769869 (accessed May 11, 2022).

5. Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

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1. Development of a Continuous Process for the Large-Scale Asymmetric Manufacture of (R)-3-Methoxy-2-(4-methylpiperazin-1-yl)propanoic Acid;Organic Process Research & Development;2024-04-08

2. Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization;Journal of Medicinal Chemistry;2023-09-22