Development and Scale-Up of the Electrochemical Dehalogenation for the Synthesis of a Key Intermediate for NS5A Inhibitors

Author:

Gütz Christoph1,Bänziger Markus2,Bucher Christoph2,Galvão Tomás R.2,Waldvogel Siegfried R.1

Affiliation:

1. Johannes Gutenberg University Mainz, Institute for Organic Chemistry, Mainz, Germany 55128

2. Novartis Pharma AG, CH-4056 Basel, Switzerland

Funder

Novartis

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference41 articles.

1. Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection

2. Qiu, Y. L.; Wang, C.; Peng, X.; Ying, L.; Or, Y. S.Hepatitis c virus inhibitors. World Patent WO 2009/102325 AI.

3. Cao, H.; Kim, I. J.; Sun, Y.; Peng, X.; Qiu, Y.L.; Tang, D.; Wang, G.; Xu, G.Processes for the preparation of 5-azaspiro[2.3]heptane-6-carboxylic acid and its derivatives. World Patent WO 2012/059281 A2.

4. Tang, D.; Xu, G.; Peng, X.; Ying, L.; Wang, C.; Cao, H.; Long, J.; Kim, I. J.; Wang, G.; Qiu, Y. L.Processes for the preparation of novel benzimidazole derivatives. World Patent WO 2013/059281 A2.

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