Affiliation:
1. Department of Chemistry Johannes Gutenberg University Duesbergweg 10–14 55128 Mainz Germany
2. Institute of Biological and Chemical Systems –Functional Molecular Systems (IBCS-FMS) Kaiserstrasse 12 76131 Karlsruhe Germany
Abstract
AbstractIsoxazol(in)es are widely featured structural motifs in natural products, agrochemicals, and pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis from readily available aldoximes is reported. Isoxazoles and isoxazolines were obtained in yields up to 81 %. The synthesis is carried out in an undivided cell as the simplest electrochemical set‐up and requires only the use of electric current as traceless oxidizing agent. The application of inexpensive and widely available electrode materials in combination with recyclable supporting electrolytes and solvents paves the path for translation of the presented reaction onto preparative scale. This is underlined by successful scale‐up to multi‐gram runs.
Funder
Deutsche Forschungsgemeinschaft
Subject
Electrochemistry,Catalysis