Development and Scale-up of a Route to ATR Inhibitor AZD6738-Reference-Cited by-同舟云学术

Development and Scale-up of a Route to ATR Inhibitor AZD6738

Published:2019-06-21 Issue:7 Volume:23 Page:1333-1342
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Goundry William R. F.¹^ORCID,Dai Kuangchu²,Gonzalez Miguel³,Legg Daniel¹,O’Kearney-McMullan Anne⁴,Morrison James¹,Stark Andrew¹,Siedlecki Paul⁴,Tomlin Paula⁴,Yang Jianbo³

Affiliation:

1. Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield SK102NA, United Kingdom

2. Changzhou SynTheAll Pharmaceutical Co. Ltd, No 589, North Yulong Road, Chunjiang Town, Xinbei District, Changzhou 213127, Jiangsu P. R. China

3. Asymchem Laboratories (Tianjin) Co. Ltd, No. 6 Dongting, Third Avenue, TEDA, Tianjin, 300457, P. R. China

4. Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield SK102NA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00075

Reference17 articles.

1. Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy

2. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

3. Foote, K. M. N.; Johannes, W. M.; Turner, P. Morpholino Pyrimidines and their use in therapy. WO 2011/154737 A1, 15 December 2011.

4. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

5. Development and Scale-up of a Biocatalytic Process To Form a Chiral Sulfoxide

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