Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors-Reference-Cited by-同舟云学术

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

Published:2017-11 Issue:414 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Henssen Anton G.¹²³⁴^ORCID,Reed Casie¹,Jiang Eileen¹^ORCID,Garcia Heathcliff Dorado³^ORCID,von Stebut Jennifer³,MacArthur Ian C.¹,Hundsdoerfer Patrick²³,Kim Jun Hyun⁵^ORCID,de Stanchina Elisa⁶^ORCID,Kuwahara Yasumichi⁷,Hosoi Hajime⁸,Ganem Neil J.⁹^ORCID,Dela Cruz Filemon¹⁰^ORCID,Kung Andrew L.¹⁰^ORCID,Schulte Johannes H.²³⁴¹¹,Petrini John H.⁵^ORCID,Kentsis Alex¹¹⁰^ORCID

Affiliation:

1. Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Berlin Institute of Health, 10178 Berlin, Germany.

3. Department of Pediatric Oncology and Hematology, Charité–Universitätsmedizin Berlin, 10117 Berlin, Germany.

4. German Cancer Consortium (DKTK), 10117 Berlin, Germany.

5. Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

7. Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

8. Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

9. Section of Hematology and Medical Oncology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02215, USA.

10. Department of Pediatrics, Weill Cornell Medical College of Cornell University and Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

11. Deutsches Krebsforschungszentrum Heidelberg, 69120 Heidelberg, Germany.

Abstract

PGBD5 DNA transposase confers therapeutically actionable dependency in solid tumors.

Funder

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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