Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir-Reference-Cited by-同舟云学术

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Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir

Published:2024-08-14 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Shaw Megan H.¹^ORCID,Fryszkowska Anna¹^ORCID,Alvizo Oscar²,Attadgie Ilana¹,Borra-Garske Margie²,Devine Paul N.¹,Duan Da²,Grosser Shane T.¹,Forstater Jacob H.¹,Hughes Gregory J.¹,Maloney Kevin M.¹^ORCID,Margelefsky Eric L.¹^ORCID,Mattern Keith A.¹^ORCID,Miller Margaret T.¹,Nawrat Christopher C.¹^ORCID,Nazor Jovana²,Orth Peter³,Ouimet Claire M.⁴,Robaire Sandra A.¹^ORCID,Ruccolo Serge¹,Schwalm Erica L.⁴^ORCID,Verma Deeptak³^ORCID,Xiao Li³,Zhang Victoria¹

Affiliation:

1. Process Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

3. Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

4. Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00075

Reference71 articles.

1. Design of an in vitro biocatalytic cascade for the manufacture of islatravir

2. Biocatalysis

3. Biocatalytic Oxidation Reactions: A Chemist's Perspective

4. Baeyer–Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation

5. Enzymatic Preparation of the Chiral (S)-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels

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