Large-Scale Stereoselective Synthesis of 1,3-Oxathiolane Nucleoside, Lamivudine, via ZrCl4-Mediated N-Glycosylation-Reference-Cited by-同舟云学术

Large-Scale Stereoselective Synthesis of 1,3-Oxathiolane Nucleoside, Lamivudine, via ZrCl4-Mediated N-Glycosylation

Published:2020-02-19 Issue:3 Volume:24 Page:387-397
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Aher Umesh P.¹^ORCID,Srivastava Dhananjai¹,Jadhav Harishchandra S.¹,Singh Girij P.¹,B. S. Jayashree²,Shenoy Gautham G.²

Affiliation:

1. Chemical Research Department, Lupin Research Park, Lupin Limited, 46A/47A, Village Nande, Taluka Mulshi, Pune, Maharashtra 412115, India

2. Department of Pharmaceutical Chemistry, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India

Funder

Lupin Limited

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00414

Reference24 articles.

1. https://www.accessdata.fda.gov/scripts/cder/ob/.

2. Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection

3. Belleau, B.; Dixit, D.; Nguyen-Ba, N.; Kraus, J. L. Design and activity of a novel class of nucleoside analogs effective against HIV-1. In 5th International Conference on AIDS; International AIDS Society, 1989, T.C.0.1.

4. Diastereoselective Synthesis of the Potent Antiviral Agent (-)-2'-Deoxy-3'-thiacytidine and Its Enantiomer

5. The Resolution and Absolute Stereochemistry of the Enantiomers ofcis-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (BCH189): Equipotent Anti-HIV Agents

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