A Continuous Process for Manufacturing Apremilast. Part I: Process Development and Intensification by Utilizing Flow Chemistry Principles-Reference-Cited by-同舟云学术

A Continuous Process for Manufacturing Apremilast. Part I: Process Development and Intensification by Utilizing Flow Chemistry Principles

Published:2024-02-02 Issue:5 Volume:28 Page:1369-1384
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hsieh Hsiao-Wu¹^ORCID,Cohen Carolyn M.¹,Griffin Daniel J.¹^ORCID,Ananthoji Padmini¹,Avci Nadide Hazal¹,Brown Derek B.²^ORCID,Ericson Ari²,Fostinis James D.¹^ORCID,Irfan Muhammad¹,Langille Neil¹,Lovette Michael A.²^ORCID,Murray James I.²^ORCID,Spada Simone¹,Thiel Oliver R.¹^ORCID,Aiello Frankie³,Daou Joseph³,Goudas-Salomon Nicole³,Pan Ende³,Sarkar Nandini³,Wimalasinghe Rasangi³,Wu Zufan Steven³,Zeng Alicia³,Beaver Matthew G.¹^ORCID

Affiliation:

1. Drug Substance Technologies - Synthetics, Amgen, Inc., Cambridge, Massachusetts 02142, United States

2. Drug Substance Technologies - Synthetics, Amgen, Inc., Thousand Oaks, California 91320, United States

3. Pivotal Attribute Sciences, Amgen, Inc., Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00400

Reference28 articles.

1. A Review on Synthetic Advances toward the Synthesis of Apremilast, an Anti-inflammatory Drug

2. Connolly, T. J.; Ruchelman, A. L.; Yong, K. H. Y.; Zhang, C. Processes for the preparation of isoindole compounds and isotopologues thereof, US 20140081032, March 20, 2014. https://patentscope.wipo.int/search/en/detail.jsf?docId=US96402461 (accessed 2023-10-12).

3. Venkateswaralu, J.; Rajendiran, C.; Connolly, T. J.; Ruchelman, A. L.; Eckert, J.; Frank, A. J. Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine. US 20130217918, Aug 22, 2015. https://patentscope.wipo.int/search/en/detail.jsf?docId=US90448237 (accessed 2023-10-09).

4. Beaver, M.; Cohen, C.; Langille, N.; Spada, S. Process for Synthesizing Apremilast. WO 2022232037, Nov 3, 2022. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2022232037&_cid=P20-LNVWSC-19504-1 (accessed 2023-10-18).

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