Bio- and Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure-Reference-Cited by-同舟云学术

Bio- and Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure

Published:2020-10-05 Issue:3 Volume:25 Page:405-410
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ruck Rebecca T.¹^ORCID,Chen Qinghao¹^ORCID,Rivera Nelo¹^ORCID,Kong Jongrock¹,Mangion Ian K.¹,Tan Lushi¹,Fleitz Fred J.¹

Affiliation:

1. Process Research & Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00314

Reference20 articles.

1. Molecular Mechanisms of Human Hypertension

2. Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one

3. Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

4. Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure

5. cPasternak, A.; Shahripour, A.; Tang, H.; Teumelsan, N. H.; Yang, L.; Zhu, Y.; Walsh, S. P. Inhibitors of the Renal Outer Medullary Potassium Channel. WO2010129379, November 11, 2010.

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