Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation-Reference-Cited by-同舟云学术

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

Published:2015-06-02 Issue:7 Volume:6 Page:747-752
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Walsh Shawn P.¹,Shahripour Aurash¹,Tang Haifeng¹,Teumelsan Nardos¹,Frie Jessica¹,Zhu Yuping¹,Priest Birgit T.,Swensen Andrew M.,Liu Jessica,Margulis Michael,Visconti Richard,Weinglass Adam,Felix John P.,Brochu Richard M.,Bailey Timothy,Thomas-Fowlkes Brande,Alonso-Galicia Magdalena,Zhou Xiaoyan,Pai Lee-Yuh,Corona Aaron,Hampton Caryn,Hernandez Melba,Bentley Ross,Chen Jing,Shah Kashmira,Metzger Joseph,Forrest Michael,Owens Karen,Tong Vincent,Ha Sookhee,Roy Sophie,Kaczorowski Gregory J.,Yang Lihu¹,Parmee Emma¹,Garcia Maria L.,Sullivan Kathleen,Pasternak Alexander¹

Affiliation:

1. Discovery Chemistry, ‡Department of Pharmacology, §Department of Cardiometabolic Diseases, ∥Pharmacokinetic, Pharmacodynamics and Drug Metabolism, ⊥Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml500440u

Reference25 articles.

1. Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics

2. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

3. Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel.

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