Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926-Reference-Cited by-同舟云学术

Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926

Published:2016-04-06 Issue:4 Volume:20 Page:786-798
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Austad Brian C.¹,Hague Andrew B.¹,White Priscilla¹,Peluso Stéphane¹,Nair Somarajan J.¹,Depew Kristopher M.¹,Grogan Michael J.¹,Charette André B.²,Yu Lin-Chen¹,Lory Caroline D.¹,Grenier Louis¹,Lescarbeau André¹,Lane Benjamin S.¹,Lombardy Richard³,Behnke Mark L.¹,Koney Nii¹,Porter James R.¹,Campbell Matthew J.¹,Shaffer Jeanne¹,Xiong Jimin¹,Helble Joseph C.¹,Foley Michael A.¹,Adams Julian¹,Castro Alfredo C.¹,Tremblay Martin R.¹

Affiliation:

1. Infinity Pharmaceuticals, Inc., 784 Memorial Drive, Cambridge, Massachusetts 02139, United States

2. Department of Chemistry, University of Montreal, Roger Gaudry Building, D-644, Faculty of Arts and Sciences, 2900 Edouard Montpetit Blvd, Montreal, P.O. Box 6128, Station Downtown, QC H3C 3J7, Canada

3. Johnson Matthey Pharma Services, 25 Patton Rd, Devens, Massachusetts 01434, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.6b00048

Reference32 articles.

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2. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

3. Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

4. Austad, B.; Behnke, M. L.; Castro, A. C.; Grogan, M. J.; Janardanannair, S.; Lescarbeau, A.; Peluso, S.; Tremblay, M.Cyclopamine Analogs. US 7,812,164, October 10, 2010.

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