Development of an Expedient Process for the Multi-Kilogram Synthesis of Chk1 Inhibitor GDC-0425-Reference-Cited by-同舟云学术

Development of an Expedient Process for the Multi-Kilogram Synthesis of Chk1 Inhibitor GDC-0425

Published:2015-05-21 Issue:6 Volume:19 Page:661-672
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Stumpf Andreas¹,Cheng Zhigang Ken¹,Wong Brian¹,Reynolds Mark¹,Angelaud Remy¹,Girotti James¹,Deese Alan¹,Gu Christine¹,Gazzard Lewis¹

Affiliation:

1. Small Molecule Process Chemistry, ‡Small Molecule Analytical Chemistry, §Department of Discovery Chemistry, Genentech, A member of the Roche Group, 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00105

Reference27 articles.

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4. dDyke, J.; Gazzard, L.; Williams, K.; Chen, H.; Kintz, S.; Drobnick, J.; Lyssikatos, J.; Goodacre, S.; Macleod, C.; Ellwood, C.US 2014/0171407 A1, June 19, 2014 A1, July 28, 2011.

5. Handbook of Reactive Chemical Hazards,3rd ed.Brederick, L., Ed.Butterworths:London, 1975; pp1132–1134.

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