Practical Preparation of a 1,3,5-Trisubstituted Pyridazin-4(1H)-one Using Selective C1 Unit Insertion and Cyclization
Author:
Affiliation:
1. Process Chemistry, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00394
Reference25 articles.
1. Phosphodiesterases in the CNS: targets for drug development
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4. Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function
5. Discovery of 1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor
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2. Oxygen-Promoted 6-endo-trig Cyclization of β,γ-Unsaturated Hydrazones/Ketoximes with Diazonium Tetrafluoroborates for Pyridazin-4(1H)-ones/Oxazin-4(1H)-ones;Organic Letters;2023-08-15
3. Silver-catalysed [3 + 2] annulation reaction of aryldiazonium salts with allenes enabled by boronate direction;Organic Chemistry Frontiers;2023
4. Discovery and Synthetic Study of Balipodect, a Novel Phosphodiesterase 10A Inhibitor;Journal of Synthetic Organic Chemistry, Japan;2021-06-01
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