Discovery of 1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor-Reference-Cited by-同舟云学术

Discovery of 1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor

Published:2014-11-10 Issue:22 Volume:57 Page:9627-9643
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kunitomo Jun¹,Yoshikawa Masato¹,Fushimi Makoto¹,Kawada Akira¹,Quinn John F.²,Oki Hideyuki¹,Kokubo Hironori¹,Kondo Mitsuyo¹,Nakashima Kosuke¹,Kamiguchi Naomi¹,Suzuki Kazunori¹,Kimura Haruhide¹,Taniguchi Takahiko¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

2. Albany Molecular Research Inc., 26 Corporate Circle, Albany, New York 12203, United States

Funder

Takeda Pharmaceutical Company Limited

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5013648

Reference43 articles.