Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine-Reference-Cited by-同舟云学术

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine

Published:2021-04-14 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Kohrt Jeffrey T.¹^ORCID,Dorff Peter H.¹,Burns Michael²^ORCID,Lee Chewah²,O’Neil Steven V.²,Maguire Robert J.²,Kumar Rajesh²,Wagenaar Melissa²,Price Loren¹,Lall Manjinder S.¹^ORCID

Affiliation:

1. Medicine Design, Pfizer Inc., 445 Eastern Point Road, Groton, Connecticut 06340, United States

2. Chemical Research and Development, Pfizer Inc., 445 Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00075

Reference30 articles.

1. The use of spirocyclic scaffolds in drug discovery

2. New and unusual scaffolds in medicinal chemistry

3. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

4. Two‐ and Three‐dimensional Rings in Drugs

5. Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

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