Catalyst-Free Cyclization- and Curtius Rearrangement-Induced Functional Group Transformation: An Improved Synthetic Strategy of First-in-Class ATX Inhibitor Ziritaxestat (GLPG-1690)-Reference-Cited by-同舟云学术

Catalyst-Free Cyclization- and Curtius Rearrangement-Induced Functional Group Transformation: An Improved Synthetic Strategy of First-in-Class ATX Inhibitor Ziritaxestat (GLPG-1690)

Published:2020-04-23 Issue:6 Volume:24 Page:997-1005
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Lei Hongrui¹,Yang Yu¹,Li Changtao¹,Jia Fang¹,Jiang Nan¹,Gong Ping¹^ORCID,Zhai Xin¹^ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

Funder

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Shenyang Pharmaceutical University

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00511

Reference23 articles.

1. Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

2. Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis

3. European Respiratory Society 2015 Annual Congress. Amsterdam, The Netherlands - September 26-30, 2015

4. Desroy, N.; Heckmann, B.; Brys, R.; Joncour, A.; Peixoto, C.; Bock, X.; Housseman, C. Compounds and Pharmaceutical Compositions Thereof for the Treatment of Inflammatory Disorders. US9,249,1412016.

5. Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rearrangement reactions: Important tool for the synthesis of piperazines;Synthetic Communications;2024-05-22

2. Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds;RSC Advances;2023

3. Hybrid imidazo[1,2‐ a ]pyridine analogs as potent ATX inhibitors with concrete in vivo antifibrosis effect;Archiv der Pharmazie;2022-06-03

4. Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors;European Journal of Medicinal Chemistry;2022-06

5. Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model;Bioorganic Chemistry;2022-03