Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis-Reference-Cited by-同舟云学术

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis

Published:2017-05-01 Issue:9 Volume:60 Page:3580-3590
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Desroy Nicolas¹^ORCID,Housseman Christopher¹,Bock Xavier¹,Joncour Agnès¹,Bienvenu Natacha¹,Cherel Laëtitia¹,Labeguere Virginie¹,Rondet Emilie¹,Peixoto Christophe¹,Grassot Jean-Marie¹,Picolet Olivier¹,Annoot Denis¹,Triballeau Nicolas¹,Monjardet Alain¹,Wakselman Emanuelle¹,Roncoroni Veronique¹,Le Tallec Sandrine¹,Blanque Roland¹,Cottereaux Celine¹,Vandervoort Nele²,Christophe Thierry²,Mollat Patrick¹,Lamers Marieke³,Auberval Marielle¹,Hrvacic Boska⁴,Ralic Jovica⁴,Oste Line²,van der Aar Ellen²,Brys Reginald²,Heckmann Bertrand¹

Affiliation:

1. Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France

2. Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium

3. Charles River Laboratories, Chesterford Research Park, CB10 1XL Saffron Walden, United Kingdom

4. Fidelta Ltd., Prilaz baruna Filipovića 29, Zagreb, HR-10000, Croatia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00032

Reference48 articles.