Development of Scalable Synthesis of 5-Butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a Dual Inhibitor of Nitric Oxide and Prostaglandin E2 Production-Reference-Cited by-同舟云学术

Development of Scalable Synthesis of 5-Butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a Dual Inhibitor of Nitric Oxide and Prostaglandin E2 Production

Published:2020-08-28 Issue:9 Volume:24 Page:1718-1724
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Dosoudil Pavel¹,Kotek Vladislav¹,Kolman Viktor²,Baszczyňski Ondřej²,Kaiser Martin Maxmilian²,Janeba Zlatko²^ORCID,Havránek Miroslav¹

Affiliation:

1. APIGENEX s.r.o., Poděbradská 173/5, 190 00 Prague 9, Czech Republic

2. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic

Funder

Technology Agency of the Czech Republic

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00324

Reference13 articles.

1. Jansa, P.; Holý, A.; Zídek, Z.; Kmoníčková, E.; Janeba, Z. Pyrimidine Compounds Inhibiting the Formation of Nitric Oxide and Prostaglandin E2, Method of Production Thereof and Use Thereof. WO2012/116666, 2012.

2. 5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production

3. Synthesis and structure–activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production

4. Polysubstituted 4,6-bis(hetero)arylpyrimidines as dual inhibitors of nitric oxide and prostaglandin E 2 production

5. Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production

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