Polysubstituted Pyrimidines as Potent Inhibitors of Prostaglandin E 2 Production: Increasing Aqueous Solubility-Reference-Cited by-同舟云学术

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Polysubstituted Pyrimidines as Potent Inhibitors of Prostaglandin E 2 Production: Increasing Aqueous Solubility

Published:2021-06-19 Issue:18 Volume:16 Page:2802-2806
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Kalčic Filip¹²,Kolman Viktor¹,Zídek Zdeněk³,Janeba Zlatko¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Flemingovo nám. 2 166 10 Prague 6 Czech Republic

2. Department of Organic Chemistry, Faculty of Science Charles University Hlavova 8 128 43 Prague 2 Czech Republic

3. Institute of Experimental Medicine of the Czech Academy of Sciences Vídeňská 1083 142 20 Prague 4 Czech Republic

Funder

Ústav organické chemie a biochemie Akademie věd České republiky

Technology Agency of the Czech Republic

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100263

Reference20 articles.

1. Strategies to Address Low Drug Solubility in Discovery and Development

2. Prediction of log P: ALOGPS Application in Medicinal Chemistry Education

3. Prodrug strategies to overcome poor water solubility

4. Improved oral drug delivery: solubility limitations overcome by the use of prodrugs

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1. Design, Synthesis, and In Vitro Antiproliferative Activity of 4,5,6-Trisubstituted 2-Aminopyrimidines as Potential TGF-β Inhibitors;Russian Journal of Organic Chemistry;2024-04

2. A straightforward trifluoromethylation at the C6 position of morphinane alkaloids, their modification and evaluation of inhibition of the SARS-CoV-2 main protease;Journal of Fluorine Chemistry;2023-10

3. Synthesis, characterization, DFT, docking, antimicrobial and thermal study of pyrimidine - carbonitrile ligand and its metal complexes;Journal of Molecular Structure;2023-07

4. Conjugates of Lupane Triterpenoids with Arylpyrimidines: Synthesis and Anti-inflammatory Activity;Steroids;2022-08

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