Evolution of a Manufacturing Route to Omarigliptin, A Long-Acting DPP-4 Inhibitor for the Treatment of Type 2 Diabetes-Reference-Cited by-同舟云学术

Evolution of a Manufacturing Route to Omarigliptin, A Long-Acting DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Published:2015-10-18 Issue:11 Volume:19 Page:1760-1768
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Chung John Y. L.,Scott Jeremy P.¹,Anderson Camille,Bishop Brian¹,Bremeyer Nadine¹,Cao Yang,Chen Qinghao,Dunn Robert,Kassim Amude,Lieberman David¹,Moment Aaron J.,Sheen Faye¹,Zacuto Michael

Affiliation:

1. Department of Process Chemistry, Merck Sharp and Dohme Ltd, Hertford Road, Hoddesdon, EN11 9BU, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00267

Reference12 articles.

1. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses

2. Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes

3. Asymmetric Synthesis of Highly Functionalized Tetrahydropyran DPP-4 Inhibitor

4. Non-oxime pyrazole based inhibitors of B-Raf kinase

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