Process Development for the Synthesis of <b>BI 1702135</b>: A Concise Design Enabled by Selective Acylation of a 2-Aminobenzimidazole Intermediate-Reference-Cited by-同舟云学术

Process Development for the Synthesis of BI 1702135: A Concise Design Enabled by Selective Acylation of a 2-Aminobenzimidazole Intermediate

Published:2023-04-05 Issue:4 Volume:27 Page:788-797
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wu Jiang-Ping¹^ORCID,Dong Wei-Tong¹,Chen Chengsheng¹,Sienkiewicz Alexander¹,Beyer Phouvieng¹,Wang Jun¹,Haddad Nizar¹^ORCID,Lorenz Jon C.¹,Reeves Jonathan T.¹^ORCID,Bunner Matthew H.²,Gonnella Nina C.²^ORCID,Weinstabl Harald³^ORCID,Garavel Géraldine³

Affiliation:

1. Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., P.O. Box 368, Ridgefield, Connecticut 06877, United States

2. Department of Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., P.O. Box 368, Ridgefield, Connecticut 06877, United States

3. Boehringer Ingelheim RCV GmbH & Co KG, 1121 Vienna, Austria

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00050

Reference23 articles.

1. Abbreviations: SWI/SNF, SWItch/Sucrose Non-Fermentable; SMARCA2/4, SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2/4; BRG1, Brahma-related gene 1; BRM: Brahma homologue.

2. The SWI/SNF complex and cancer

3. The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers

4. Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer

5. SMARCA4 and SMARCA2 deficiency in non–small cell lung cancer: immunohistochemical survey of 316 consecutive specimens

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