A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC-Reference-Cited by-同舟云学术

A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC

Published:2024-03-20 Issue:4 Volume:28 Page:1239-1252
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Lee Miseon¹,Wu Jiang-Ping¹^ORCID,Lee Jaehee¹^ORCID,Wang Jun¹,White Jada A. H.¹^ORCID,Rugg Kyle W.¹^ORCID,Sienkiewicz Alexander¹,Lorenz Jon C.¹,Greb Peter²^ORCID,Bunner Matthew H.¹,Hirsh David A.¹^ORCID,Gonnella Nina C.¹^ORCID,Nordstrom Fredrik L.¹^ORCID,Kofink Christiane²,Weinstabl Harald²^ORCID,Reeves Jonathan T.¹^ORCID

Affiliation:

1. Departments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States

2. Medicinal Chemistry, Boehringer Ingelheim Pharma RCV GmbH & Co KG, Vienna 1121, Austria

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00048

Reference27 articles.

1. A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

2. Process Development for the Synthesis of BI 1702135: A Concise Design Enabled by Selective Acylation of a 2-Aminobenzimidazole Intermediate

3. Synthesis and Applications of tert-Butanesulfinamide

4. Catalytic Synthesis of (R) and (S) citronellol by homogeneous hydrogenation over amidophosphinephosphinite and diaminodiphosphine rhodium complexes

5. Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Allylic Alcohols by an Enantioselective Isomerization/Transfer Hydrogenation Mechanism

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