Facile and practical access to chiral benzofused oxa-heterocycles <i>via</i> an asymmetric hydrogenation and intramolecular S<sub>N</sub>Ar cascade-Reference-Cited by-同舟云学术

Facile and practical access to chiral benzofused oxa-heterocycles via an asymmetric hydrogenation and intramolecular S_NAr cascade

Published:2024 Issue: Volume: Page:
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Fangyuan¹,Wu Ting¹,Lu Bin¹,Yu Jianchao¹,Xiao Renwei¹,Yi Boxuan¹,Zhang Xumu¹^ORCID,Chen Gen-Qiang¹²^ORCID

Affiliation:

1. Medi-X Pingshan and Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518055, China

2. Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518000, People's Republic of China

Abstract

Herein, we report a tandem asymmetric hydrogenation and SNAr reaction, providing valuable six- and five-membered chiral benzofused cyclic ethers with high yields and enantioselectivities (up to 99% yield and up to 99% ee).

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Commission

Shenzhen Natural Science Foundation

Key Area Research and Development Program of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01665J

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