Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles-Reference-Cited by-同舟云学术

Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles

Published:2021-05-19 Issue:6 Volume:25 Page:1383-1390
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Rajappan Kumar¹^ORCID,Tanis Steven P.¹²^ORCID,Roberts Scott¹,Karmali Priya¹,Chivukula Padmanabh¹,Zhuang Jin³,Xin Mingxing³,Zheng Manman³,Edmonds Ian⁴

Affiliation:

1. Arcturus Therapeutics Inc., 10628 Science Center Drive #250, San Diego, California 92121, United States

2. SPTanis PharmaChem Consulting LLC, 1750 Oriole Court, Carlsbad, California 92011, United States

3. Pharmaron Bejing Co., Ltd., (China), 6 Taihe Rd, BDA, Beijing 100176, P. R. China

4. Bridge Organics, 311 West Washington Street, Vicksburg, Michigan 49097, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00076

Reference27 articles.

1. Liposomal Formulations for Nucleic Acid Delivery

2. Rational design of cationic lipids for siRNA delivery

3. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

4. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

5. Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia

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