Continuous flow synthesis of the ionizable lipid ALC-0315-Reference-Cited by-同舟云学术

Continuous flow synthesis of the ionizable lipid ALC-0315

Published:2024 Issue:4 Volume:9 Page:959-966
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Wolf Jakob B.¹²^ORCID,Lee Ju Weon³,Plutschack Matthew B.¹^ORCID,Cambié Dario¹^ORCID,Seidel-Morgenstern Andreas³⁴,Seeberger Peter H.¹²^ORCID

Affiliation:

1. Department of Biomolecular Systems, Max-Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany

2. Department of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany

3. Department of Physical and Chemical Foundations of Process Engineering, Max-Planck-Institute for Dynamics of Complex Technical Systems, Sandtorstraße 1, 39106 Magdeburg, Germany

4. Institute of Process Engineering, Otto von Guericke University Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany

Abstract

The ionizable lipid ALC-0315 is the major component of the lipid nanoparticles used to encapsulate the mRNA in the Biontech–Pfizer COVID-19 vaccine.

Funder

Deutsche Forschungsgemeinschaft

Max-Planck-Gesellschaft

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RE/D3RE00630A

Reference37 articles.

1. mRNA vaccines for infectious diseases: principles, delivery and clinical translation

2. mRNA vaccines — a new era in vaccinology

3. Lipids and Lipid Derivatives for RNA Delivery

4. Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

5. Lipid Nanoparticle Systems for Enabling Gene Therapies

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