Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core-Reference-Cited by-同舟云学术

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

Published:2012-08-21 Issue:34 Volume:116 Page:18440-18450
ISSN:1932-7447
Container-title:The Journal of Physical Chemistry C
language:en
Short-container-title:J. Phys. Chem. C

Author:

Leung Alex K. K.¹,Hafez Ismail M.¹,Baoukina Svetlana²,Belliveau Nathan M.³,Zhigaltsev Igor V.¹,Afshinmanesh Elham²,Tieleman D. Peter²,Hansen Carl L.⁴,Hope Michael J.⁵,Cullis Pieter R.¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada V6T 1Z3

2. Department of Biological Sciences and Institute for Biocomplexity and Informatics, University of Calgary, Calgary, Canada T2N 1N4

3. Precision NanoSystems, Vancouver, Canada V6T 1Z3

4. Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada V6T 1Z1

5. AlCana Technologies, Vancouver, Canada, V6T 1Z3

Publisher

American Chemical Society (ACS)

Subject

Surfaces, Coatings and Films,Physical and Theoretical Chemistry,General Energy,Electronic, Optical and Magnetic Materials

Link

https://pubs.acs.org/doi/pdf/10.1021/jp303267y

Reference31 articles.

1. RNAi-mediated gene silencing in non-human primates

2. Rational design of cationic lipids for siRNA delivery

3. A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA

4. Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles

5. Formation of drug–arylsulfonate complexes inside liposomes: A novel approach to improve drug retention

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