Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase-Reference-Cited by-同舟云学术

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

Published:2021-05-20 Issue:21 Volume:143 Page:8193-8207
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zhu Wei¹,Doubleday Peter F.²,Butrin Arseniy³,Weerawarna Pathum M.¹,Melani Rafael D.²,Catlin Daniel S.³,Dwight Timothy A.¹,Liu Dali³^ORCID,Kelleher Neil L.¹²^ORCID,Silverman Richard B.¹²⁴^ORCID

Affiliation:

1. Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States

2. Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States

3. Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States

4. Department of Pharmacology, Northwestern University, Chicago, Illinois 60611, United States

Funder

National Institute on Drug Abuse

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c03572