Design, Synthesis, and Mechanistic Studies of (<i>R</i>)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase-Reference-Cited by-同舟云学术

Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase

Published:2024-04-17 Issue:5 Volume:19 Page:1066-1081
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Devitt Allison N.¹^ORCID,Vargas Abigail L.²,Zhu Wei¹,Des Soye Benjamin James³^ORCID,Butun Fatma Ayaloglu³,Alt Tyler²,Kaley Nicholas²,Ferreira Glaucio M.⁴^ORCID,Moran Graham R.²^ORCID,Kelleher Neil L.³^ORCID,Liu Dali²^ORCID,Silverman Richard B.¹³⁵^ORCID

Affiliation:

1. Department of Chemistry, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States

2. Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States

3. Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States

4. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil

5. Department of Pharmacology, Northwestern University, Chicago, Illinois 60611, United States

Funder

Division of Chemistry

National Cancer Institute

Centros de Pesquisa, Inova??o e Difus?o, Funda??o Amaz?nia Paraense de Amparo ? Pesquisa

National Institute on Drug Abuse

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.4c00022

Reference54 articles.

1. Disease Burden of Hepatocellular Carcinoma: A Global Perspective

2. Hepatocellular Carcinoma: A Global Disease in Need of Individualized Treatment Strategies

3. Screening for hepatocellular carcinoma: The rationale for the American Association for the Study of Liver Diseases recommendations

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5. Strategies to increase the resectability of hepatocellular carcinoma

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