Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution-Reference-Cited by-同舟云学术

Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution

Published:2019-11-11 Issue:4 Volume:6 Page:577-587
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Cheng Qipeng¹,Xu Chen¹,Chai Jiachang²,Zhang Rong²,Wai chi Chan Edward¹,Chen Sheng³^ORCID

Affiliation:

1. State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

2. Department of Clinical Medicine, Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China

3. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong

Funder

Research Grants Council, University Grants Committee

Natural Science Foundation of Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.9b00345

Reference36 articles.

1. A standard numbering scheme for the class A β-lactamases

2. CTX-M-190, a Novel β-Lactamase Resistant to Tazobactam and Sulbactam, Identified in an Escherichia coli Clinical Isolate