Genetic and Functional Characterization of bla CTX-M-199 , a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1 -Bearing IncI2 Plasmid-Reference-Cited by-同舟云学术

Genetic and Functional Characterization of bla CTX-M-199 , a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1 -Bearing IncI2 Plasmid

Published:2017-07 Issue:7 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cai Jiachang¹,Cheng Qipeng²³,Shen Yingbo⁴,Gu Danxia⁵,Fang Ying¹,Chan Edward Wai-Chi³,Chen Sheng²³

Affiliation:

1. Clinical Microbiology Laboratory, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China

2. Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People's Republic of China

3. State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

4. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China

5. Center for Cancer Biology and Innovative Therapeutics, Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Clinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou, China

Abstract

ABSTRACT We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a bla CTX-M-64 variant gene found in a conjugative mcr-1 -bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.

Funder

CRF

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00562-17

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