Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring bla CTX-M-55 and mcr-1-Reference-Cited by-同舟云学术

Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring bla CTX-M-55 and mcr-1

Published:2016-08 Issue:8 Volume:60 Page:5014-5017
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sun Jian¹²,Li Xing-Ping¹²,Yang Run-Shi¹²,Fang Liang-Xing¹²,Huo Wei¹²,Li Shu-Min¹²,Jiang Peng¹²,Liao Xiao-Ping¹²,Liu Ya-Hong¹²³

Affiliation:

1. National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China

2. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, People's Republic of China

3. Jiangsu Co-innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, People's Republic of China

Abstract

ABSTRACT We report the complete nucleotide sequence of a plasmid, pA31-12, carrying bla CTX-M-55 and mcr-1 from a chicken Escherichia coli isolate. pA31-12 has an IncI2 replicon that displays extensive sequence similarity with pHN1122-1-borne bla CTX-M-55 and pHNSHP45-borne mcr-1 . Insertion sequences IS Ecp1 and IS Apl1 are responsible for the mobilization of bla CTX-M-55 and mcr-1 , respectively. The colocalization of mcr-1 with an extended-spectrum β-lactamase gene on a conjugative plasmid may accelerate the dissemination of both genes by coselection.

Funder

The National Natural Science Foundation and Natural Science Foundation of Guangdong Province, China

The Program for Changjiang Scholars and Innovative Research Team at the University of Ministry of Education of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00774-16

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