Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa

Published:2021-08-17 Issue:9 Volume:7 Page:2666-2685
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Soukarieh Fadi¹²^ORCID,Mashabi Alaa³,Richardson William³,Oton Eduard Vico¹,Romero Manuel¹²,Roberston Shaun N.¹²,Grossman Scott³,Sou Tomas⁴,Liu Ruiling³,Halliday Nigel¹,Kukavica-Ibrulj Irena⁵,Levesque Roger C.⁵,Bergstrom Christel A. S.⁴,Kellam Barrie³^ORCID,Emsley Jonas³²,Heeb Stephan¹,Williams Paul¹²,Stocks Michael J.³²^ORCID,Cámara Miguel¹²

Affiliation:

1. School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K.

2. The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K.

3. School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, U.K.

4. Department of Pharmacy, Uppsala University, Uppsala SE-751 23, Sweden

5. Institut de Biologie Integrative et des Systemes, Universite Laval, Quebec G1 V 0A6, Canada

Funder

Engineering and Physical Sciences Research Council

Medical Research Council

European Commission

Joint Programming Initiative on Antimicrobial Resistance

Innovate UK

Biotechnology and Biological Sciences Research Council

Hartree Centre

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.1c00175

Reference55 articles.

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2. Pew Trusts. Antibiotics Currently in Global Clinical Development. https://www.pewtrusts.org/en/research-and-analysis/data-visualizations/2014/antibiotics-currently-in-clinical-development (accessed March 15, 2021).

3. World Health Organisation. (2017) Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa in health care facilities.

4. Nosocomial Infections Due to Multidrug-ResistantPseudomonas aeruginosa: Epidemiology and Treatment Options

5. Anti-virulence Strategies to Target Bacterial Infections

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