Triblock copolymer micelles enhance solubility, permeability and activity of a quorum sensing inhibitor against <i>Pseudomonas aeruginosa</i> biofilms-Reference-Cited by-同舟云学术

Triblock copolymer micelles enhance solubility, permeability and activity of a quorum sensing inhibitor against Pseudomonas aeruginosa biofilms

Published:2024 Issue:3 Volume:2 Page:444-455
ISSN:2755-371X
Container-title:RSC Applied Polymers
language:en
Short-container-title:RSC Appl. Polym.

Author:

Kasza Karolina¹²^ORCID,Soukarieh Fadi²^ORCID,Romero Manuel²³⁴^ORCID,Hardie Kim R.²^ORCID,Gurnani Pratik⁵^ORCID,Cámara Miguel²^ORCID,Alexander Cameron¹^ORCID

Affiliation:

1. Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK

2. National Biofilms Innovation Centre, School of Life Sciences, Biodiscovery Institute, University Park, University of Nottingham, Nottingham NG7 2RD, UK

3. Department of Microbiology and Parasitology, Faculty of Biology-CIBUS, Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain

4. Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain

5. UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK

Abstract

Combination therapies offer potential solutions to the growing threats of antimicrobial resistance. We describe polymer delivery materials for Quorum Sensing Inhibitors used in combination with ciprofloxacin to enhance potency in bacterial biofilms.

Funder

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Innovate UK

Cystic Fibrosis Trust

Cystic Fibrosis Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LP/D3LP00208J

Reference42 articles.

1. Challenges and solutions in polymer drug delivery for bacterial biofilm treatment: A tissue-by-tissue account

2. The biofilm matrix

3. Bacterial and Fungal Biofilm Infections

4. Sociomicrobiology: the connections between quorum sensing and biofilms

5. The Evolution of Quorum Sensing in Bacterial Biofilms