Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Published:2024-01-03 Issue:2 Volume:67 Page:1008-1023
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Soukarieh Fadi¹²^ORCID,Mashabi Alaa³^ORCID,Richardson William³,Oton Eduard Vico¹,Romero Manuel¹²,Dubern Jean-Frédéric¹,Robertson Shaun N.¹²,Lucanto Simone¹²,Markham-Lee Zoe³,Sou Tomás⁴^ORCID,Kukavica-Ibrulj Irena⁵,Levesque Roger C.⁵,Bergstrom Christel A. S.⁴^ORCID,Halliday Nigel¹,Kellam Barrie³^ORCID,Emsley Jonas³²,Heeb Stephan¹^ORCID,Williams Paul¹²,Stocks Michael J.³²^ORCID,Cámara Miguel¹²

Affiliation:

1. School of Life Sciences, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, U.K.

2. The National Biofilms Innovation Centre, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, U.K.

3. School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, U.K.

4. Department of Pharmacy, Uppsala University, Uppsala SE-751 23, Sweden

5. Institut de Biologie Intégrative et des SystèmesUniversité Laval, Quebec G1V 0A6, Canada

Funder

Medical Research Council

Ministerio de Universidades

University of Nottingham

Wellcome Trust

National Biofilms Innovation Centre

Faculty of Pharmacy, Umm Al-Qura University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00973

Reference51 articles.

1. Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives

2. Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective

3. Anti-virulence strategies to combat bacteria-mediated disease

4. Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition

5. Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control