Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase-Reference-Cited by-同舟云学术

Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase

Published:2017-06-21 Issue:7 Volume:3 Page:467-478
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Sanders Sara¹,Vierling Ryan J.¹,Bartee David¹,DeColli Alicia A.¹,Harrison Mackenzie J.²,Aklinski Joseph L.²,Koppisch Andrew T.²,Freel Meyers Caren L.¹^ORCID

Affiliation:

1. Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States

2. Department of Chemistry, Northern Arizona University, Flagstaff, Arizona 86011, United States

Funder

Division of Chemistry

National Institute of General Medical Sciences

Institute for Basic Biomedical Sciences, Johns Hopkins Medicine

Office of the Vice President for Research, Northern Arizona University

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.6b00168

Reference75 articles.

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3. Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS

4. Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

5. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

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