Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis

Author:

Park Yumi1,Pacitto Angela2,Bayliss Tracy3,Cleghorn Laura A. T.3,Wang Zhe4,Hartman Travis4,Arora Kriti1,Ioerger Thomas R.5,Sacchettini Jim6,Rizzi Menico7,Donini Stefano7,Blundell Tom L.2,Ascher David B.2,Rhee Kyu4,Breda Ardala6,Zhou Nian6,Dartois Veronique8,Jonnala Surendranadha Reddy1,Via Laura E.19,Mizrahi Valerie9,Epemolu Ola3,Stojanovski Laste3,Simeons Fred3,Osuna-Cabello Maria3,Ellis Lucy3,MacKenzie Claire J.3,Smith Alasdair R. C.3,Davis Susan H.3,Murugesan Dinakaran3,Buchanan Kirsteen I.3,Turner Penelope A.3,Huggett Margaret3,Zuccotto Fabio3,Rebollo-Lopez Maria Jose10,Lafuente-Monasterio Maria Jose10,Sanz Olalla10,Diaz Gracia Santos10,Lelièvre Joël10,Ballell Lluis10,Selenski Carolyn11,Axtman Matthew11,Ghidelli-Disse Sonja12,Pflaumer Hannah12,Bösche Markus12,Drewes Gerard12,Freiberg Gail M.13,Kurnick Matthew D.13,Srikumaran Myron13,Kempf Dale J.13,Green Simon R.3,Ray Peter C.3,Read Kevin3,Wyatt Paul3,Barry Clifton E.19,Boshoff Helena I.1

Affiliation:

1. Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892-3206, United States

2. Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom

3. Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee DD1 5EH, United Kingdom

4. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, New York 10065, United States

5. Department of Computer Science and Engineering, Texas A&M University, College Station, Texas 77843, United States

6. Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, United States

7. Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy

8. Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey 07103, United States

9. MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7700, South Africa

10. Diseases of the Developing World, GlaxoSmithKline, Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain

11. GlaxoSmithKline, 5 Crescent Drive, Philadelphia, Pennsylvania 19112, United States

12. Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany

13. AbbVie Molecular Characterization, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

Funder

Medical Research Council

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

National Institute of Allergy and Infectious Diseases

National Health and Medical Research Council

Foundation for the National Institutes of Health

Bill and Melinda Gates Foundation

Wellcome Trust

South African Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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