Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities

Author:

Boshoff Helena I. M.1ORCID,Young Katherine2,Ahn Yong-Mo1,Yadav Veena D.1,Crowley Brendan M.2,Yang Lihu2,Su Jing2,Oh Sangmi1ORCID,Arora Kriti1,Andrews Jenna1,Manikkam Michelle3,Sutphin Michelle3,Smith Anthony J.4,Weiner Danielle M.3,Piazza Michaela K.3,Fleegle Joel D.3,Gomez Felipe3,Dayao Emmannual K.3,Prideaux Brendan2,Zimmerman Matthew5,Kaya Firat5ORCID,Sarathy Jansy5,Tan Vee Yang1,Via Laura E.3,Tschirret-Guth Richard2,Lenaerts Anne J.4,Robertson Gregory T.4,Dartois Véronique4ORCID,Olsen David B.2,Barry Clifton E1ORCID

Affiliation:

1. Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institutes of Health, Bethesda, Maryland 20892, United States

2. Merck & Co., Inc., West Point, Pennsylvania 19486, United States

3. Tuberculosis Imaging Program, Division of Intramural Research, National Insititute of Allergy and Infectious Disease, National Insititutes of Health, Bethesda, Maryland 20892, United States

4. Mycobacterial Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Ft Collins, Colorado 80521, United States

5. Hackensack Meridian Health Center for Discovery & Innovation, Nutley, New Jersey 07110, United States

Funder

Division of Intramural Research

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

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