Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics-Reference-Cited by-同舟云学术

Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics

Published:2018-04-30 Issue:7 Volume:4 Page:1114-1120
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Sonousi Amr¹,Sarpe Vikram A.¹,Brilkova Margarita²,Schacht Jochen³,Vasella Andrea⁴,Böttger Erik C.²,Crich David¹^ORCID

Affiliation:

1. Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States

2. Institut für Medizinische Mikrobiologie, Universität Zürich, Gloriastrasse 28/30, 8006 Zürich, Switzerland

3. Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, United States

4. Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.8b00052

Reference74 articles.

1. Holdren, J. P., and Lander, E. S. (2014) Report to the President on Combatting Antibiotic Resistance, pp 1–65, President’s Council of Advisors on Science and Technology, Washington DC.

2. Antibiotic Resistance Threats in the United States, 2013 (2013) pp 1–114, Centers for Disease Control and Prevention, Atlanta, GA.

3. Antibiotics for Emerging Pathogens

4. Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

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