Facile and selective <i>N</i>-alkylation of gentamicin antibiotics <i>via</i> chemoenzymatic synthesis-Reference-Cited by-同舟云学术

Facile and selective N-alkylation of gentamicin antibiotics via chemoenzymatic synthesis

Published:2022 Issue:24 Volume:24 Page:9542-9551
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Stojanovski Gorjan¹²^ORCID,Hailes Helen C.²^ORCID,Ward John M.¹^ORCID

Affiliation:

1. Department of Biochemical Engineering, University College London, London WC1E 6BT, UK

2. Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK

Abstract

A two-step chemoenzymatic route to enable regioselective modification of aminoglycoside antibiotic analogues was developed without the use of protecting groups. This approach allows rapid generation of novel antibiotic analogues.

Funder

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/GC/D2GC03600B

Reference46 articles.

1. Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria.*

2. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities

3. Evaluation of amphiphilic aminoglycoside–peptide triazole conjugates as antibacterial agents

4. Design, Synthesis, and Antibacterial Activities of Neomycin−Lipid Conjugates: Polycationic Lipids with Potent Gram-Positive Activity

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