Structure-Based Design, Synthesis, and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]- 3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase-Reference-Cited by-同舟云学术

Structure-Based Design, Synthesis, and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]- 3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Published:2001-07-10 Issue:16 Volume:44 Page:2544-2554
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mai Antonello¹,Sbardella Gianluca¹,Artico Marino¹,Ragno Rino¹,Massa Silvio¹,Novellino Ettore¹,Greco Giovanni¹,Lavecchia Antonio¹,Musiu Chiara¹,La Colla Massimiliano¹,Murgioni Chiara¹,La Colla Paolo¹,Loddo Roberta¹

Affiliation:

1. Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, I-00185 Roma, Italy, Dipartimento di Studi di Chimica e Tecnologie delle Sostanze Biologicamente Attive, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, I-00185 Roma, Italy, Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via Aldo Moro, I-53100 Siena, Italy, Dipartimento di Chimica Farmaceutica e Tossicologica, Università...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010853h

Reference47 articles.

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2. Structural biology of HIV 1 1Edited by P. E. Wright

3. 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

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