Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase-Reference-Cited by-同舟云学术

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Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Published:2023-04 Issue: Volume:133 Page:106413
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Hao Qing-Qing,Chen Xiao-Mei,Pannecouque Christophe,De Clercq Erik,Wang Shuai,Chen Fen-Er

Funder

Ningxia Medical University

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference35 articles.

1. UNAIDS global HIV & AIDS statistics-2022 fact sheet. Available from: .

2. The search for potent, small molecule NNRTIs: a review;Prajapati;Bioorg. Med. Chem.,2009

3. Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases;Sarafianos;Curr. Opin. Struct. Biol.,2004

4. The journey of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) from lab to clinic;Namasivayam;J. Med. Chem.,2019

5. Structural modifications of diarylpyrimidines (DAPYs) as HIV-1 NNRTIs: synthesis, anti-HIV activities and SAR;Lu;Bioorg. Med. Chem.,2017

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1. Deciphering the enigmas of non‐nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance;Medicinal Research Reviews;2024-08-26

2. Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility;Bioorganic Chemistry;2024-06

3. Improving the anti-HIV-1 activity and solubility of poorly water-soluble DAPYs by heteroaromatic replacement strategy: From naphthalene-DAPYs to quinoline-DAPYs;Bioorganic Chemistry;2023-11

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