Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors-Reference-Cited by-同舟云学术

Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Published:2021-03 Issue:3 Volume:32 Page:1020-1024
ISSN:1001-8417
Container-title:Chinese Chemical Letters
language:en
Short-container-title:Chinese Chemical Letters

Author:

Li Daxiong,Zhang Chunsheng,Ding Wei,Huang Siming,Yu Le,Lu Nan,Pan Wenkai,Li Yiming,De Clercq Erik,Pannecouque Christophe,Zhang Hongbing,Wang Yueping,He Yanping,Chen Fener^ORCID

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

General Chemistry

Reference33 articles.

1. Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

2. Allosteric Suppression of HIV-1 Reverse Transcriptase Structural Dynamics upon Inhibitor Binding

3. Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

4. Approved Antiviral Drugs over the Past 50 Years

5. Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

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