Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
Author:
Affiliation:
1. Neuroscience Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm9015334
Reference20 articles.
1. Phosphodiesterases in the CNS: targets for drug development
2. Phosphodiesterase 5 Inhibitors for Erectile Dysfunction
3. Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors
4. Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).
5. Expression of cGMP-Specific Phosphodiesterase 9A mRNA in the Rat Brain
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