Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia-Reference-Cited by-同舟云学术

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia

Published:2023-01-10 Issue:2 Volume:66 Page:1157-1171
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Layton Mark E.¹^ORCID,Kern Jeffrey C.¹,Hartingh Timothy J.¹,Shipe William D.¹^ORCID,Raheem Izzat¹^ORCID,Kandebo Monika²,Hayes Robert P.³,Huszar Sarah⁴,Eddins Donnie⁴,Ma Bennett⁵,Fuerst Joy⁶,Wollenberg Gordon K.⁷,Li Jing⁸,Fritzen Jeff⁸,McGaughey Georgia B.⁹^ORCID,Uslaner Jason M.²^ORCID,Smith Sean M.²,Coleman Paul J.¹,Cox Christopher D.¹

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

2. Neuroscience, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

3. Structural Chemistry, Merck & Co., Inc., Boston, Massachusetts 02115, United States

4. In Vivo Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

5. Pharmacokinetics, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

6. Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

7. Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

8. Discovery Process Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

9. Chemistry Modeling and Informatics, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

Funder

Merck Sharp and Dohme

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01521

Reference27 articles.

1. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

2. Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use

3. Emerging Biology of PDE10A

4. The Prevalence and Correlates of Nonaffective Psychosis in the National Comorbidity Survey Replication (NCS-R)

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