New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer-Reference-Cited by-同舟云学术

New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer

Published:2014-07-29 Issue:15 Volume:57 Page:6531-6552
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

La Regina Giuseppe¹,Bai Ruoli²,Coluccia Antonio¹,Famiglini Valeria¹,Pelliccia Sveva³,Passacantilli Sara¹,Mazzoccoli Carmela⁴,Ruggieri Vitalba⁴,Sisinni Lorenza⁴,Bolognesi Alessio⁵,Rensen Whilelmina Maria⁵,Miele Andrea⁵,Nalli Marianna¹,Alfonsi Romina⁶,Di Marcotullio Lucia⁶,Gulino Alberto⁶,Brancale Andrea⁷,Novellino Ettore³,Dondio Giulio⁸,Vultaggio Stefania⁹,Varasi Mario⁹,Mercurio Ciro¹⁰,Hamel Ernest²,Lavia Patrizia⁵,Silvestri Romano¹

Affiliation:

1. Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy

2. Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States

3. Dipartimento di Farmacia, Università di Napoli Federico II, Via Domenico Montesano 49, I-80131 Napoli, Italy

4. Laboratorio di Ricerca Pre-Clinica e Traslazionale, IRCCS, Centro di Riferimento Oncologico della Basilicata, I-85028 Rionero in Vulture, Italy

5. Institute of Molecular Biology and Pathology (IBPM), CNR National Research Council of Italy, Sapienza Università di Roma, Via degli Apuli 4, I-00185 Roma, Italy

6. Dipartimento di Medicina Sperimentale e Patologia, Sapienza Università di Roma, Viale Regina Elena 324, I-00161 Roma, Italy

7. Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, United Kingdom

8. NiKem Research Srl, Via Zambeletti 25, I-20021 Baranzate, I-20021 Milano, Italy

9. European Institute of Oncology, Via Adamello 16, I-20139 Milano, Italy

10. Genextra Group, DAC SRL, Via Adamello 16, I-20139 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500561a

Reference42 articles.

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2. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin

3. Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain

4. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

5. High-Resolution Model of the Microtubule

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