Design and synthesis of novel N-benzyl-2,5-dihydro-1H-pyrrole-linked benzopyrimidine conjugates as antimicrobial agents: study combining in vitro and in silico analysis-Reference-Cited by-同舟云学术

Design and synthesis of novel N-benzyl-2,5-dihydro-1H-pyrrole-linked benzopyrimidine conjugates as antimicrobial agents: study combining in vitro and in silico analysis

Published:2024 Issue:32 Volume:48 Page:14262-14276
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Chortani Sarra¹²³,Ben Salah Sami¹²,Hajlaoui Amel³,Horchani Mabrouk³,Edziri Hayet⁴,Daïch Adam¹²^ORCID,Ben Jannet Hichem³^ORCID,Romdhane Anis³^ORCID,Lawson Ata Martin¹²^ORCID,Othman Mohamed¹²^ORCID

Affiliation:

1. Normandie Univ., UNILEHAVRE, URCOM, 76600 Le Havre, France

2. UR 3221, INC3M, FR-CNRS 3038 UFR ST, BP: 1123, 25 rue Philippe Lebon, F-76063 Le Havre Cedex, France

3. Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity, Team: Medicinal Chemistry and Natural Products (LR11ES39), Department of Chemistry, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia

4. Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy, 5000 Monastir, Tunisia

Abstract

A new series of N-benzyl-2,5-dihydro-1H-pyrrole-linked benzopyrimidines 5 and 6 were synthesized via 1,3-dipolar cycloaddition reaction and evaluated for their in vitro antimicrobial activity.

Funder

Enseignement Supérieur et de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D4NJ02744B

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